计算机化学研究员 Scientist of Computational Chemistry

工作地点：上海         所属类型：Chemistry         发布时间：2019-07-05

岗位描述：

Responsibilities:

1. Work closely with clients, such as major international pharmaceutical and biotech companies on their drug discovery programs

2. Responsible for providing computational chemistry support to structure-, ligand- and fragment-based drug discovery projects as well as virtual screening efforts

3. Utilize software for in silico prediction of ADME, biology, and safety properties

4. Develop QSAR model for data analysis

5. Work collaboratively with chemists and project teams to design compounds with improved potency, selectivity, functional activity and/or ADME properties

6. Support various database and software systems to collect, disseminate, and analyze all pre-clinical small molecule discovery data to our internal and external scientists

任职资格：

Requirements:

1. M.S. (or above) in Computational Chemistry, Organic Chemistry or a related discipline

2. M.S. at least three years or PhD at least three years of hands-on experience in two or more of the following areas: structure-based drug design including docking, homology modeling, molecular dynamics simulation, free energy calculation; ligand-based drug design including pharmacophore modeling, QSAR, 3D-QSAR, pharmacophore- or shape-based database searching, combinatorial and fragment library design, focused library construction, R-group decomposition, pairwise matching, cliff analysis

3. Familiarity with state-of-the-art modeling and cheminformatics tools such as Maestro, MOE, Gold, JChem, Vortex, Spotfire, Knime, etc.

4. Strong problem solving skills and the ability to work in a fast-paced environment

5. Preferred Requirements:

6. harma or biotech experience with a focus on computational chemistry and strong understanding of drug design principles

7. Solid understanding of medicinal chemistry concepts and demonstrated success in addressing medicinal chemistry design challenges

8. Familiarity with common programming languages such as Perl, Java and C++, as well as functional familiarity with web technologies

9. Fluency in written and spoken English